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Education:
Ph.D
The Ohio State University (1997)
M.S. The Ohio State University
(1992)
B.S. The State University of New York Geneseo (1985)
Courses Taught:
General Biology 1
Immunology
Developmental Biology
Introduction to Research
Research Interests:
The focus of my research is the role of
the immune system in the development of disease. The immune system
is normally thought of as ameliorating disease. However, in many
chronic situations the activity of immune cells actually exacerbates
the disease process, leading to a chronic state of tissue damage
and wound healing. This destructive cycle in tissue causes cell
death and fibrosis (the deposition of extracellular matrix proteins
between cells). In chronic situations, this tissue damage disrupts
the tissue organization needed for normal organ functionality.
A good example of this, is a group of intestinal diseases (including
Crohn’s Disease and Ulcerative Colitis) known as Inflammatory
Bowel Diseases (IBD). Patients suffering from IBD, often shed
the epithelial cells lining their intestine, which can lead to
painful intestinal ulcerations. One of the seminal events leading
to IBD is a florid influx of immune cells into the intestine.
We have recently published a manuscript showing that a group of
enzymes (known as meprins) are intimately involved in the migration
of immune cells into the intestine during experimental IBD. This
work appeared as the cover article of the Journal of Immunology
in April of 2004. In addition, my research has shown that meprins
cleave a group of proteins that affect the directional migration
of immune cells. We are now performing studies to determine if
meprin intervention methods can be used to treat IBD and other
diseases with immunological etiologies. For further details of
my current research projects, please refer to my personal website.
Professional Affiliations:
Awards:
National Kidney Foundation Fellowship (1999-2000)
National Research Service Award (2000-2002)
Alyce G. Specter Award for Renal Research (1999-2000 and 2001-2002)
Broad Medical Award for Inflammatory Bowel Disease Research (2004-2005)
Related Publications:
Crisman J.M., Jackwood R.J., Lana D.P., Jackwood
D.J. Evaluation of VP2 Epitopes of Infectious Bursal Disease Virus
using In Vitro Expression and radioimmunoprecipitation. Archives
of Virology 128(3-4):333-344, 1993.
Crisman J.M., Wilkie N.M., Elder P., Kolattukudy P.E. Identification
of the amino acids involved in the binding of hMIP-1? to neutrophils
using hMIP-1? /hMIP-1? chimeras. Molec Cell Biochem 195:245-256,
1999.
Crisman J.M., Ricardo S.D. and Diamond J.R. Chemokines and renal
inflammation in proteinuric disorders: searching for the inciting
stimulus J.Exp.Clin. Med. 133:13-14, 1999.
Ricardo SD, Franzoni DF, Roesener CD, Crisman JM, Diamond JR.
Angiotensinogen and AT(1) antisense inhibition of osteopontin
translation in rat proximal tubular cells. Am J Physiol Renal
Physiol 278(5):F708-16, 2000.
Crisman JM, Richards LL, Valach DP, Franzoni DF and Diamond JR.
Chemokine expression in the obstructed kidney. Exp Nephrol 9:241-248
2001.
Bertenshaw GP, Turk BE, Hubbard SJ, Matters GL, Bylander JE, Crisman
JM, Cantley LC and Bond JS. Marked differences between metalloproteases
meprin A and B in substrate and peptide bond specificity. J Biol
Chem 276(16):13248-13255 2001.
Norman LP, Matters GL, Crisman JM and Bond JS. Expression of Meprins
in Health and Disease. In: Cell Surface Proteases. Zucker E, eds.
Academic Press, San Diego, CA 2002.
Norman LP, Matters GL, Crisman JM and Bond JS. Expression of Meprins
in Health and Disease. In: Cell Surface Proteases. Curr Top Dev
Biol 54:145-166 2003.
Crisman JM, Richards LL, Norman LP, Wang XJ and Bond JS. Meprin
Beta is an important mediator of leukocyte extravasation in the
lymph node- slated for the upcoming April edition of the Journal
of Immunology, 2004.
Crisman JM, Richards LL, Norman LP, Wang XJ and Bond JS. Meprin
Beta is an important mediator of leukocyte extravasation in the
lymph node- Featured on the cover of the April 1st issue of the
Journal of Immunology 2004.
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