Atypical antipsychotic drugs
Clozapine (Clozaril, 1990)
- Sometimes dramatic improvement
- Relieves + and - symptoms of schizophrenia
- Agranulocytosis, NMS
- Acts on DA, 5-HT, ACh, and histamine
Risperidone (Risperdal, 1994)
- Inhibits D2 and serotonin-2 receptors
- Low side effects: First-line treatment