Pharmacodynamics: Mechanisms
Mediated by blockade of adenosine receptor
- A normal dose blockades 50% of receptors
Adenosine is not a neurotransmitter but a neuromodulator or autacoid.
Adenosine, and thus caffeine, act on NE, DA, ACh , glutamate, and GABA
DA activity is especially increased, but not in the nucleus accumbens