Julien’s principles of CNS depressants

CNS depressants are additive with each other and with the behavioral state of the user. Supradditive = synergistic.
CNS depressants are antagonists of the behavioral stimulants, but in a non-specific fashion.
Rebound or withdrawal is unlikely after a single dose of a CNS depressant.
Dependence, psychological dependence, and tolerance do occur to CNS depressants.