History of opioids
Opium, the sap of the seed pod of Papaver somniferum, referred to as early as 3000 B.C. and found in Spanish burial sites dated 4200 B.C.
Greeks and Romans used opium to produce constipation, sleep, and ultimately as a panacea: Hippocrates, Pliny, and Galen
May be the gall of Scripture (Matt. 27:34)